ASSOCIATION OF ADIPOKINES AND VITAMIN D IN CHILDREN WITH AUTISM SPECTRUM DISORDER.

Researchers tested blood samples from 50 autistic children and 30 non-autistic children. They found autistic children had lower vitamin D levels and higher levels of certain proteins (leptin and visfatin) in their blood. The study suggests these differences might be related to autism, but more research is needed to understand what this means.

This cross-sectional study examined serum levels of vitamin D and adipokines (leptin, irisin, visfatin) in 50 children with autism spectrum disorder compared to 30 healthy controls. Results showed autistic children had significantly lower vitamin D and irisin levels, while leptin and visfatin levels were significantly higher compared to controls. The authors suggest these biomarker differences may contribute to ASD onset and severity, though the study design prevents determination of causality.

Findings suggest potential utility of vitamin D screening in autistic children and possible role of adipokines as biomarkers. However, clinical application requires replication in larger studies with longitudinal designs to establish causality and clinical significance.

Small sample size (50 ASD, 30 controls), cross-sectional design prevents causal inference, limited demographic information provided, unclear study methodology, and lack of information about potential confounding factors such as diet, physical activity, or medications.

This study tested the serum concentration of vitamin D, leptin as a biomolecule in serum of children with autism spectrum disorder (ASD). Blood samples were obtained from (50) patients with autism, compared with healthy group as a control (30). Leptin, irisin and visfatin was detected. The amounts of leptin and visfatin were much higher in autistic group than healthy control group.

Also, there was a significant reduction in vitamin D and irisin in the serum vitamin D, and irisin in autistic patients in comparison with control groups (p<0.0001 and p<0.05). Children presented with ASD presented with lower levels of serum vitamin D, and irisin. Also, another common factor in the diagnosis in autistic children, were higher levels of visfatin, and leptin possibly contributing to the onset and severity of ASD.