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[Research progress on the association between prenatal nutritional factors and autism spectrum disorder].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]2025

Zhao W L, Pan C L, Li D D, Yan J, Huang H M

What this study means for families

This review looks at how a mother's diet during pregnancy might affect the risk of autism in children. Some nutrients like multivitamins, vitamin D, healthy fats, and iron may help reduce autism risk. However, different studies show mixed results, so more research is needed to be certain about these connections.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Research summary

This Chinese review examines the relationship between maternal nutrition during pregnancy and autism spectrum disorder (ASD) risk. The review suggests that certain prenatal nutritional factors may influence ASD development, with multivitamin supplementation and adequate vitamin D intake potentially reducing risk. Polyunsaturated fatty acids (PUFA) and iron consumption also show similar protective associations. However, the authors acknowledge that research findings remain inconsistent across studies.

The review aims to synthesize current knowledge on key nutrients that may affect ASD risk during pregnancy, providing a foundation for developing targeted perinatal nutritional intervention strategies.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Key findings

  • 1

    Prenatal multivitamin supplementation may reduce ASD risk

    Confidence: limitedRelevance: Supports consideration of multivitamin supplementation during pregnancy
  • 2

    Adequate vitamin D intake during pregnancy may be protective against ASD

    Confidence: limitedRelevance: Important for prenatal care recommendations regarding vitamin D status
  • 3

    PUFA and iron consumption show similar protective effects

    Confidence: limitedRelevance: Suggests importance of balanced maternal nutrition including essential fatty acids and iron

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Clinical implications

Findings support the importance of comprehensive prenatal nutrition counseling. Healthcare providers should consider discussing multivitamin supplementation, vitamin D status, and adequate PUFA and iron intake with pregnant women, while noting the preliminary nature of current evidence.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Limitations

Research findings are inconsistent across studies. As a narrative review, specific study quality and methodology details are not provided. Sample sizes and effect sizes are not reported.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Original abstract

Autism spectrum disorder (ASD) is a neurodevelopmental condition originating in early life, presenting significant challenges for affected families and society. ASD is characterized by atypical brain development occurring throughout gestation. Maternal diet during pregnancy plays a crucial role in ASD pathogenesis. Specifically, prenatal multivitamin supplementation and adequate vitamin D intake may reduce ASD risk; similar protective effects have been associated with polyunsaturated fatty acid (PUFA) and iron consumption.

Although research findings are inconsistent, prenatal nutritional interventions represent a promising strategy for mitigating the future risk of mental health and other disorders in offspring. Therefore, this article reviews key nutrients implicated in ASD risk during pregnancy, to provide a theoretical foundation for developing precise perinatal nutritional intervention plans.

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Evidence Grade

Emerging

limited

Grade assigned by AutismInsights based on study type and published abstract.

Study Details

Type
Review
Journal
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Year
2025
PMID
40955030
DOI
10.3760/cma.j.cn112150-20241105-00879

MeSH Terms

HumansAutism Spectrum DisorderPregnancyFemalePrenatal Nutritional Physiological PhenomenaDietary SupplementsVitamin DMaternal Nutritional Physiological PhenomenaFatty Acids, Unsaturated