[Circadian rhythm disturbances and neurodevelopmental disorders].

This research review looks at how sleep and body clock problems are connected to developmental conditions like autism and ADHD. Many children with these conditions have trouble sleeping, and this can make their symptoms worse. The researchers explain how disrupted sleep patterns and changes in 'clock genes' might cause some of the thinking, behavior, and emotional difficulties seen in these conditions. They suggest that treatments focusing on fixing sleep and body clock problems could help children with autism and other developmental conditions.

This review examines the relationship between circadian rhythm disturbances and neurodevelopmental disorders (NDDs), including autism spectrum disorder, ADHD, and intellectual developmental disorder. The authors highlight that sleep rhythm disruptions are commonly comorbid with NDDs and are used as indicators of disease severity and treatment outcomes. The review focuses on how circadian rhythm disruptions and mutations in circadian clock genes contribute to cognitive, behavioral, and emotional symptoms in NDDs, particularly through effects on the dopamine system. The authors discuss the potential for targeting circadian systems as novel therapeutic approaches for treating NDDs.

Sleep rhythm assessments could be valuable for monitoring NDD severity and treatment progress. Targeting circadian systems represents a promising new therapeutic avenue for NDDs. Clinicians should consider sleep disturbances as potentially significant factors in NDD presentation and management, particularly given the dopamine system involvement.

As a review article, this study does not present original research data. The abstract does not specify the methodology used for literature selection or the quality assessment of included studies. No sample sizes or specific study populations are reported.

Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and intellectual developmental disorder (IDD), are highly prevalent and lack effective treatments, posing significant health challenges. These disorders are frequently comorbid with disruptions in sleep rhythms, and sleep-related indicators are often used to assess disease severity and treatment efficacy. Recent evidence has highlighted the crucial roles of circadian rhythm disturbances and circadian clock gene mutations in the pathogenesis of NDDs. This review focuses on the mechanisms by which circadian rhythm disruptions and circadian clock gene mutations contribute to cognitive, behavioral, and emotional disorders associated with NDDs, particularly through the dysregulation of dopamine system.

Additionally, we discussed the potential of targeting the circadian system as novel therapeutic strategies for the treatment of NDDs.