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Structural Validity of the Psychopathology in Autism Checklist Among Children and Adolescents.

Journal of intellectual disability research : JIDR2025

Halvorsen Marianne Berg, Kildahl Arvid Nikolai, Thimm Jens C, Helverschou Sissel Berge

What this study means for families

Researchers tested a mental health assessment tool called the PAC with 600 children who have intellectual disabilities, including 194 with autism. The tool showed good reliability for measuring mental health problems in most areas (except psychosis symptoms). The PAC worked well alongside other standard assessments and appears suitable for evaluating mental health in autistic children with intellectual disabilities.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Research summary

This validation study examined the Psychopathology in Autism Checklist (PAC) among 600 children aged 2-19 years with intellectual and developmental disabilities, including 194 with autism spectrum disorder. The research assessed the PAC's structural validity and internal consistency using confirmatory factor analysis. Results showed acceptable fit indices for a three-factor solution, with adequate internal consistency for most subscales (except psychosis). The PAC demonstrated meaningful relationships with established measures including the Strengths and Difficulties Questionnaire, Vineland Adaptive Behaviour Scales, IQ assessments, and autism symptom measures.

The findings provide preliminary support for using the PAC to assess mental health in autistic children and adolescents with intellectual disabilities.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Key findings

  • 1

    The PAC demonstrated acceptable structural validity with a three-factor solution in children with autism and intellectual disabilities

    Confidence: moderateRelevance: Provides evidence for the PAC's appropriateness as a mental health assessment tool for this population
  • 2

    Internal consistency was adequate for most PAC subscales, with the exception of the psychosis subscale

    Confidence: moderateRelevance: Indicates reliable measurement across most mental health domains, though psychosis assessment may need refinement
  • 3

    The PAC showed meaningful relationships with established measures of behaviour, adaptive functioning, and autism symptoms

    Confidence: moderateRelevance: Supports the PAC's validity and utility alongside other assessment tools in clinical practice

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Clinical implications

The PAC appears to be a promising tool for assessing mental health in autistic children with intellectual disabilities. Clinicians should exercise caution when interpreting the psychosis subscale. Further validation studies are needed before widespread clinical implementation, but the tool shows potential for improving mental health assessment in this underserved population.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Limitations

This is the first validation study of the PAC in this population, providing only preliminary evidence. The psychosis subscale showed poor internal consistency. The study focused on structural validity but did not examine other important psychometric properties like test-retest reliability or sensitivity to change.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Original abstract

The use of instruments developed for people with autism spectrum disorder (ASD) and intellectual and developmental disabilities (IDDs) is recommended for assessing mental health in these groups. This is the first study to investigate the structural validity and internal consistency of the Psychopathology in Autism Checklist (PAC) among autistic children and adolescents with IDDs. A total of 600 children aged 2-19 years (M = 9.2 years, SD = 4.5 years, 66% male) with IDDs (full-scale IQ M = 81.29, SD = 18.65) participated, including 194 individuals with ASD. Parents completed the PAC, Strengths and Difficulties Questionnaire (SDQ) and Vineland Adaptive Behaviour Scales (VABS).

Full-scale IQ was assessed using an individualised intelligence test, and the extent of autism characteristics was assessed using the Autism Diagnostic Observation Schedule-2. Confirmatory factor analyses revealed acceptable fit indices for a three-factor solution. The internal consistency was adequate for most of the PAC subscales. The PAC showed meaningful overlap and differentiation with the SDQ, VABS, measures of intellectual functioning and a measure of autism symptoms.

Overall, satisfactory internal consistency and validity were found for the PAC (with the exception of the psychosis subscale). These findings provide preliminary support for the use of the PAC in children and adolescents with ASD and IDDs.

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Evidence Grade

Emerging

moderate

Grade assigned by AutismInsights based on study type and published abstract.

Study Details

Journal
Journal of intellectual disability research : JIDR
Year
2025
PMID
40637594
DOI
10.1111/jir.70012

MeSH Terms

HumansAdolescentChildMaleFemaleChecklistAutism Spectrum DisorderChild, PreschoolReproducibility of ResultsYoung AdultPsychometricsIntellectual DisabilityPsychiatric Status Rating ScalesDevelopmental Disabilities