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EmergingCase Report

Investigating the Overlap ofand Autism Spectrum Disorder: A Case Report.

Medicina (Kaunas, Lithuania)2025

Moro Marianna, de Gioia Alessia, D'Amario Giulia, Napoli Valentina, Venezia Ilaria, Mirra Federica, D'Ambrosio Martina, Venditti Romina, Sestito Simona, De Stefano Andrea, Di Domenico Sara, Romeo Domenico, Mercuri Eugenio, Brogna Claudia

What this study means for families

This study looked at a 14-year-old girl who showed signs of both autism and hikikomori (extreme social withdrawal lasting more than 6 months). The researchers found that autism and hikikomori share many similar features, and brain scans show both conditions affect areas of the brain involved in social skills. However, there are currently no specific treatments available for young people who have both conditions.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Research summary

This case report describes a 14-year-old girl presenting with characteristics of both hikikomori and Autism Spectrum Disorder (ASD). Hikikomori is a form of prolonged social withdrawal (>6 months) with significant functional impairment, with global prevalence ranging from 1.1% to 6.7%. The authors note that hikikomori and ASD share numerous characteristics, supported by functional neuroimaging studies showing alterations in brain regions related to social functioning in both conditions. The study highlights the potential overlap between these conditions but notes that specific treatments for hikikomori in ASD patients are currently unavailable.

The authors emphasize the need for further research to understand the relationship, boundaries, and possible overlap between hikikomori and ASD.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Key findings

  • 1

    Hikikomori and ASD share numerous characteristics supported by functional neuroimaging studies showing alterations in brain regions related to social functioning

    Confidence: limitedRelevance: Suggests potential neurobiological overlap between conditions that may inform assessment and intervention approaches
  • 2

    No specific treatments are currently approved for hikikomori in ASD patients

    Confidence: limitedRelevance: Highlights a significant gap in evidence-based interventions for individuals presenting with both conditions
  • 3

    Global prevalence of hikikomori ranges from 1.1% to 6.7%

    Confidence: limitedRelevance: Indicates hikikomori is a relatively common condition that clinicians should be aware of, particularly when assessing social withdrawal in autism

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Clinical implications

This case highlights the need for clinicians to consider hikikomori when assessing prolonged social withdrawal in autistic adolescents. The overlap between conditions suggests similar underlying neurobiological mechanisms may be involved. Clinical assessment should distinguish between autism-related social difficulties and hikikomori-specific withdrawal patterns to develop appropriate intervention strategies.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Limitations

Single case report of one individual limits generalizability. No specific diagnostic criteria or assessment tools described. Lacks detailed intervention outcomes or follow-up data. The abstract does not provide sufficient methodological details about the case presentation or assessment procedures used.

Summary by AutismInsights from published abstract. This is not a substitute for reading the original paper.

Original abstract

is a form of social withdrawal lasting more than 6 months with significant associated functional impairment. To date, numerous studies confirm the presence of this condition not only in Japan, where it was first described, but also globally abroad. This is an underestimated clinical condition, and it is emerging especially in adolescents and young adults, representing an increasing management problem for families and society. Prevalence ranges from 1.1% to 6.7%.can be associated with other neurodevelopmental disorders, such as Autism Spectrum Disorder (ASD).

Indeed, ASD andshare numerous characteristics confirmed by functional neuroimaging studies that have highlighted in both conditions the presence of alterations in cerebral regions related to social functioning. We present a case report regarding the history of a 14-year-old girl with characteristics compatible with ASD and. At present, there are no specific treatments approved forin ASD patients. Further studies are necessary to understand the link between the two conditions, the boundary, and possible overlap.

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Evidence Grade

Emerging

emerging

Grade assigned by AutismInsights based on study type and published abstract.

Study Details

Type
Case Report
Journal
Medicina (Kaunas, Lithuania)
Year
2025
PMID
40282928
DOI
10.3390/medicina61040637

MeSH Terms

HumansAutism Spectrum DisorderFemaleAdolescentSocial IsolationJapan