Hormonal disorders in autism spectrum disorders.

This review looked at how hormone problems might be connected to autism. Researchers found that people with autism often have different levels of certain hormones like melatonin (which helps with sleep), growth hormones, and others that affect mood and behavior. Some of these hormones are lower in autistic people than in others. The researchers think understanding these hormone differences might help develop new treatments for autism.

This narrative review examines the relationship between hormonal disorders and autism spectrum disorder (ASD). The authors conducted a literature review using multiple databases to investigate how various hormones may contribute to ASD pathophysiology and serve as potential therapeutic targets. The review identified several hormones of interest including melatonin, serotonin, thyroid hormones, oxytocin, vasopressin, and insulin-like growth factor-1 (IGF-1). The authors report that IGF-1 levels are low in individuals with ASD, and melatonin levels are reduced.

The review aims to provide an overview of hormonal associations with ASD and explore their potential as therapeutic interventions to reduce ASD-related effects.

Findings suggest hormonal assessment may be valuable in autism evaluation and management. Hormone replacement or modulation therapies could represent novel treatment approaches, particularly for sleep disorders and growth concerns in autistic individuals.

This is a narrative review without systematic methodology details. No sample size reported, and the level of evidence for specific hormonal findings is unclear. The review format limits the strength of conclusions that can be drawn about specific hormone-autism relationships.

Autism spectrum disorder (ASD) is a pervasive neurobehavioral condition characterized by disruption of behavioral and emotional patterns in individuals with this condition. Given that various environmental and genetic factors play a fundamental role in the pathophysiology of ASD, it can be said that ASD is a multifaceted disease. This study used scientific databases including Google Scholar, PubMed, Scopus, and Semantic Scholar. In this review, we aimed to select manuscripts based on our field and relevant to the topic of our article.

Emerging studies have shown that many neural, anatomical, and chemical factors play a role in the development of ASD. In this regard, an increasing body of studies has pointed out the relationship between chemical factors, including hormones, which play an important role in ASD. These hormones include melatonin, serotonin, thyroid, oxytocin, vasopressin, insulin-like growth hormone (IGF-1), etc. For instance, IGF-1 levels are low in ASD individuals, or melatonin levels are reduced in ASD individuals.

Therefore, with take into account these findings, in this review, we decided to check over the association of these hormones to ASD and have a concise overview of their potential as therapeutic solutions to reduce the effects of ASD.